Description
Fluconazole is a prescription azole antifungal medication that may be used to treat serious fungal or yeast infections including those that affect the vagina, mouth or throat, lungs, bladder, or blood. It is available as an oral tablet, suspension, or injectable form.
- Examples of conditions treated by fluconazole include vaginal candidiasis, oropharyngeal candidiasis, esophageal candidiasis, and cryptococcal meningitis.
Fluconazole may also be used to prevent fungal infections in people with a weak immune system caused by cancer or cancer treatment including radiation therapy, bone marrow transplant, conditions such as AIDS, or children on life support (extracorporeal membrane oxygenation [ECMO]).
Fluconazole works by targeting a key enzyme (lanosterol 14-alpha-demethylase) responsible for building a crucial cell wall component (ergosterol) in fungi. By blocking this enzyme, Fluconazole prevents the fungus from forming a normal cell wall, leading to the buildup of abnormal sterols. These abnormal sterols weaken the fungal cell wall, hindering its growth. Fluconazole’s mechanism of action means it has a much greater effect on this enzyme in fungi compared to the same enzyme in human cells. This selectivity helps minimize side effects.





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